Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MME | P08473 | 1/20 | 0.49 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | MMP14 | P50281 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28426554 | 0.82 | ALDH1A1 (0.56) | SMN1; SMN2HPGDRAB9ACYP3A4CYP2C19 | |
| SCHEMBL8241745 | 0.81 | EPHX1 (0.58) | SMN1; SMN2HPGDRAB9ACYP3A4CYP2C19 | |
| SCHEMBL11890375 | 0.79 | RAB9A (0.58) | SMN1; SMN2HPGDRAB9ACYP3A4CYP2C19 | |
| SCHEMBL9083123 | 0.78 | HPGD (0.54) | SMN1; SMN2HPGDRAB9ACYP3A4CYP2C19 | |
| SCHEMBL2447962 | 0.78 | HPGD (0.54) | SMN1; SMN2HPGDRAB9ACYP3A4CYP2C19 | |
| SCHEMBL2447963 | 0.78 | HPGD (0.54) | SMN1; SMN2HPGDRAB9ACYP3A4CYP2C19 | |
| SCHEMBL14748252 | 0.76 | HPGD (0.55) | SMN1; SMN2HPGDRAB9ACYP3A4CYP2C19 | |
| SCHEMBL3241644 | 0.76 | EPHX1 (0.53) | SMN1; SMN2HPGDRAB9ACYP3A4CYP2C19 | |
| SCHEMBL5907626 | 0.76 | HPGD (0.55) | SMN1; SMN2HPGDRAB9ACYP3A4CYP2C19 | |
| SCHEMBL11890370 | 0.76 | RAB9A (0.54) | SMN1; SMN2HPGDRAB9ACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0457195-B1 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5656604-A | HYPOTENSIVE AGENT; ENDOTHELIN ANTAGONIST | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5430022-A | Endothelin antagonists; hypotensive agents; treatment for angina pectoris, brain disorders, asthma, renal failure | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| US-5284828-A | Hypotensive agents | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 1994-02-08 | — | — | US | disclosed |
| EP-0457195-A2 | Peptides having endothelin antagonist activity, a process for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-11-21 | — | — | EP | disclosed |