Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.55 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1272249 | 0.94 | OPRL1 (0.65) | ALDH1A1SMN1; SMN2OPRL1OPRM1OPRD1 | |
| SCHEMBL7191677 | 0.87 | ALDH1A1 (0.61) | ALDH1A1SMN1; SMN2OPRL1OPRM1OPRK1 | |
| SCHEMBL9395676 | 0.83 | OPRL1 (0.71) | OPRL1OPRM1OPRD1OPRK1SIRT2 | |
| SCHEMBL7480936 | 0.80 | OPRL1 (0.59) | OPRL1OPRM1OPRD1OPRK1SIRT2 | |
| SCHEMBL8676782 | 0.78 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2OPRL1OPRM1OPRD1 | |
| SCHEMBL8611338 | 0.78 | OPRL1 (0.52) | ALDH1A1SMN1; SMN2OPRL1OPRM1OPRD1 | |
| SCHEMBL9395659 | 0.77 | OPRL1 (0.55) | OPRL1OPRM1OPRD1OPRK1SIRT2 | |
| SCHEMBL30910142 | 0.76 | OPRL1 (0.86) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL26092381 | 0.76 | OPRL1 (0.86) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL9395620 | 0.76 | SIRT2 (0.77) | ALDH1A1SMN1; SMN2OPRL1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4948794-A | NEUROLEPTIC AGENTS | A/S FERROSAN (DK) | 1990-08-14 | — | — | US | claimed |
| US-5852017-A | 2,3(1H,4H)-quinoxalinediones | BASF AKTIENGESELLSCHAFT (DE) | 1998-12-22 | — | — | US | disclosed |
| EP-0572852-B1 | Quinoxalin-2,3(1H,4H)-diones used as medicine | BASF AG (DE) | 1998-10-21 | — | — | EP | disclosed |
| US-5714489-A | 2,3(1H,4H)quinoxalinedione | BASF AKTIENGESELLSCHAFT (DE) | 1998-02-03 | — | — | US | disclosed |
| EP-0315959-B1 | Quinoxaline compounds and their preparation and use | NOVO NORDISK AS (DK) | 1994-03-02 | — | — | EP | disclosed |
| EP-0572852-A1 | Quinoxalin-2,3(1H,4H)-diones used as medicine | BASF Aktiengesellschaft (DE) | 1993-12-08 | — | — | EP | disclosed |
| US-5026704-A | Neuroleptic agent, quisqualate-antagonist | NOVO NORDISK A/S (DK) | 1991-06-25 | — | — | US | disclosed |
| US-4948794-A | NEUROLEPTIC AGENTS | A/S FERROSAN (DK) | 1990-08-14 | — | — | US | disclosed |
| EP-0315959-A2 | Quinoxaline compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-05-17 | — | — | EP | disclosed |