Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.63 |
| ▸ | DHODH | Q02127 | 7/20 | 0.60 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22471917 | 0.85 | KDM4E (0.59) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL4461409 | 0.82 | KDM4E (0.63) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL11668642 | 0.81 | ALDH1A1 (0.49) | KDM4EDHODHPOLBHSD17B10ALDH1A1 | |
| SCHEMBL8616258 | 0.81 | MEN1 (0.46) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL10611217 | 0.80 | SMN1; SMN2 (0.46) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| SCHEMBL11668909 | 0.80 | ALDH1A1 (0.47) | KDM4EDHODHHSD17B10ALDH1A1MEN1 | |
| SCHEMBL10758845 | 0.79 | PDE10A (0.64) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| Cinchophen SCHEMBL29376617 | 0.78 | KDM4E (1.00) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| Cinchophen SCHEMBL25519 | 0.78 | KDM4E (1.00) | KDM4ELMNASMN1; SMN2PDE10ADHODH | |
| Cinchophen SCHEMBL7588217 | 0.78 | KDM4E (1.00) | KDM4ELMNASMN1; SMN2PDE10ADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |
| US-4009020-A | QUINOLINE-4-CARBOXYLIC ACID OR SALTS | AMCHEM PRODUCTS, INC. (US) | 1977-02-22 | — | — | US | disclosed |