Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.68 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30912307 | 0.98 | KMO (0.70) | KMOACMSDKMT2AKDM4EGLA | |
| SCHEMBL27893460 | 0.98 | KMO (0.65) | KMOACMSDKMT2AKDM4EGLA | |
| SCHEMBL184302 | 0.89 | KMO (0.53) | KMOACMSDKDM4ESMN1; SMN2HIF1A | |
| SCHEMBL2727410 | 0.87 | KMO (0.58) | KMOACMSDKMT2AKDM4EGLA | |
| SCHEMBL4392929 | 0.87 | KMO (0.55) | KMOACMSDKDM4ESMN1; SMN2HIF1A | |
| SCHEMBL10068703 | 0.87 | KMO (0.54) | KMOACMSDKMT2AKDM4ESMN1; SMN2 | |
| Biguanide SCHEMBL8614065 | 0.85 | KMO (0.53) | KMOACMSDKMT2AKDM4EGLA | |
| SCHEMBL2723391 | 0.85 | KMO (0.56) | KMOACMSDKMT2AKDM4EGLA | |
| SCHEMBL10068933 | 0.84 | KMO (0.51) | KMOACMSDKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL27629794 | 0.82 | KMO (0.49) | KMOACMSDKMT2AKDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102958912-B | Benzohydrol derivatives, a preparation process and pharmaceutical use thereof | SHANGHAI HENGRUI PHARM CO LTD | 2015-01-14 | — | — | CN | disclosed |
| CN-102958912-A | Benzohydrol derivatives, a preparation process and pharmaceutical use thereof | SHANGHAI HENGRUI PHARM CO LTD | 2013-03-06 | — | — | CN | disclosed |
| US-5731350-A | Substituted benzenedicarboxylic acid diguanides, process for their preparation, their use as a medicament or diagnostic, and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-24 | — | — | US | disclosed |