Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12932913 | 0.83 | ALDH1A1 (0.40) | KMT2ASMN1; SMN2HTTMEN1CYP3A4 | |
| SCHEMBL10126871 | 0.81 | MAPT (0.54) | KMT2AHTTMEN1MAPTRAB9A | |
| SCHEMBL6701038 | 0.79 | KIT (0.38) | KMT2ASMN1; SMN2HTTMEN1CYP3A4 | |
| SCHEMBL2015299 | 0.78 | MAPT (0.44) | KMT2AMEN1CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL6697703 | 0.76 | ALDH1A1 (0.40) | KMT2ASMN1; SMN2HTTMEN1CYP3A4 | |
| SCHEMBL6701656 | 0.76 | ALDH1A1 (0.40) | KMT2ASMN1; SMN2HTTMEN1CYP3A4 | |
| SCHEMBL11556501 | 0.76 | AR (0.39) | KMT2ASMN1; SMN2HTTMEN1MAPT | |
| SCHEMBL14255794 | 0.75 | EGLN2 (0.52) | SMN1; SMN2HTTSCN9AABCC9KCNJ11 | |
| SCHEMBL25374366 | 0.74 | IDH2 (0.36) | KMT2AMEN1MAPTFPR2SCN9A | |
| SCHEMBL31368961 | 0.74 | MAPT (0.47) | KMT2AHTTMEN1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5837702-A | HAVING POTASSIUM CHANNEL ACTIVATING ACTIVITY USEFUL AS CARDIOVASCULAR AGENTS AND TREATMENT OF ISCHEMIA | BRISTOL-MYERS SQUIBB CO. (US) | 1998-11-17 | — | — | US | disclosed |
| EP-0648758-A1 | 4-Arylamino-benzopyran and related compounds | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-04-19 | — | — | EP | disclosed |