Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 8/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10080932 | 0.78 | NOTUM (0.63) | NOTUMLMNAALDH1A1SMN1; SMN2CYP11B1 | |
| SCHEMBL8617331 | 0.74 | ACHE (0.46) | KDM4E | |
| SCHEMBL8655991 | 0.73 | NOTUM (0.53) | NOTUMLMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8133031 | 0.73 | NOTUM (0.60) | NOTUMALDH1A1SMN1; SMN2KDM4EEGFR | |
| SCHEMBL14754335 | 0.72 | NOTUM (0.55) | NOTUMLMNAALDH1A1SMN1; SMN2CYP11B1 | |
| SCHEMBL31689853 | 0.72 | NOTUM (0.61) | NOTUMLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL14665068 | 0.71 | NOTUM (0.58) | NOTUMLMNAALDH1A1SMN1; SMN2CYP11B1 | |
| SCHEMBL6608567 | 0.71 | NOTUM (0.53) | NOTUMLMNAALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL6608569 | 0.71 | NOTUM (0.53) | NOTUMLMNAALDH1A1SMN1; SMN2EGFR | |
| SCHEMBL25786385 | 0.70 | NOTUM (0.59) | NOTUMLMNAALDH1A1XIAPBIRC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |