Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.81 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.81 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | HTR7 | P34969 | 3/20 | 0.75 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.73 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.69 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.69 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8002897 | 0.92 | MAPT (0.79) | MAPTKMT2AL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL8009539 | 0.92 | MAPT (0.79) | MAPTKMT2AL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL25097473 | 0.92 | MAPT (0.79) | MAPTKMT2AL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL3970369 | 0.91 | L3MBTL1 (0.97) | MAPTKMT2AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL4577971 | 0.91 | L3MBTL1 (0.97) | MAPTKMT2AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL11240406 | 0.91 | L3MBTL1 (0.97) | MAPTKMT2AL3MBTL1ALDH1A1KDM4E | |
| SCHEMBL12577217 | 0.91 | MAPT (1.00) | MAPTKMT2AL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL12575381 | 0.91 | MAPT (1.00) | MAPTKMT2AL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL12259197 | 0.90 | MAPT (0.76) | MAPTKMT2AL3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL28632862 | 0.90 | MAPK1 (0.91) | MAPTKMT2AL3MBTL1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0089634-B1 | PHENOXYPROPANOLAMINE DERIVATIVES | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1986-07-02 | — | — | EP | claimed |
| EP-0089634-A1 | Phenoxypropanolamine derivatives | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1983-09-28 | — | — | EP | claimed |
| JP-58164583-A | — | — | None | — | — | JP | disclosed |
| EP-0833639-A1 | PHENOXY PIPERAZINE DERIVATIVES FOR TREATING DISORDERS OF THE DOPAMINE SYSTEM | F. HOFFMANN-LA ROCHE AG (CH) | 1998-04-08 | — | — | EP | disclosed |
| US-5614526-A | IN TREATING DISORDERS OF THE DOPAMINE SYSTEM | HOFFMANN-LA ROCHE INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996041630-A1 | PHENOXY PIPERAZINE DERIVATIVES FOR TREATING DISORDERS OF THE DOPAMINE SYSTEM | F. HOFFMANN-LA ROCHE AG (CH) | 1996-12-27 | — | — | WO | disclosed |
| US-4642307-A | HYPOTENSIVE AGENTS | NIPPON SHINYAKU CO., LTD. (JP) | 1987-02-10 | — | — | US | disclosed |
| US-4642307-A | HYPOTENSIVE AGENTS | NIPPON SHINYAKU CO., LTD. (JP) | 1987-02-10 | — | — | US | disclosed |
| EP-0089634-B1 | PHENOXYPROPANOLAMINE DERIVATIVES | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1986-07-02 | — | — | EP | disclosed |
| JP-S58164583-A | PHENOXYPROPANOLAMINE DERIVATIVE | NIPPON SHINYAKU CO LTD | 1983-09-29 | — | — | JP | disclosed |
| EP-0089634-A1 | Phenoxypropanolamine derivatives | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1983-09-28 | — | — | EP | disclosed |
| EP-0089634-A1 | Phenoxypropanolamine derivatives | NIPPON SHINYAKU COMPANY, LIMITED (JP) | 1983-09-28 | — | — | EP | disclosed |
| US-3951983-A | HYPOTENSIVE | PFIZER INC. (US) | 1976-04-20 | — | — | US | disclosed |
| US-3930004-A | Method of using phenoxypropanolpiperazine compounds to lower blood pressure | PFIZER | 1975-12-30 | — | — | US | disclosed |
| US-3856794-A | 1-PHENOXY-3-ARYLPIPERAZINYL-2-PROPANOL HYPOTENSIVES | UNITED STIRLING AB., A CORP. OF SWEDEN (SE) | 1974-12-24 | — | — | US | disclosed |