Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8534653 | 0.81 | NAALAD2 (0.43) | TSHR | |
| SCHEMBL18768867 | 0.79 | CHRM1 (0.32) | CHRM1 | |
| SCHEMBL9575752 | 0.77 | TSHR (0.33) | TSHR | |
| SCHEMBL17953984 | 0.76 | ALDH1A1 (0.40) | CHRM1 | |
| SCHEMBL12891365 | 0.76 | ALDH1A1 (0.40) | CHRM1 | |
| SCHEMBL19233793 | 0.76 | SMN1; SMN2 (0.35) | TSHR | |
| SCHEMBL15092131 | 0.73 | TSHR (0.37) | TSHR | |
| SCHEMBL9753145 | 0.73 | TSHR (0.33) | TSHR | |
| SCHEMBL24486625 | 0.73 | HDAC7 (0.41) | TSHRCHRM1 | |
| SCHEMBL12050688 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0437290-B1 | Process for the preparation of 5-oxohexane nitriles and the compound 2,4-dimethyl-5-oxohexane nitrile | DSM NV (NL) | 1998-05-06 | — | — | EP | claimed |
| US-5334721-A | Reacting a methyl ketone and an alpha,beta-unsaturated nitrile in the presence of a basic catalyst; preparation of a 2-methyl-3,5-dialkylpyridine; cyclization; dehydrogenation | STAMICARBON B.V. (NL) | 1994-08-02 | — | — | US | claimed |
| US-5254712-A | Using basic catalyst | STAMICARBON B.V. (NL) | 1993-10-19 | — | — | US | claimed |
| EP-0437290-A1 | Process for the preparation of 5-oxohexane nitriles and the compound 2,4-dimethyl-5-oxohexane nitrile | DSM N.V. (NL) | 1991-07-17 | — | — | EP | claimed |
| JP-4253946-A | — | — | None | — | — | JP | disclosed |
| EP-2032989-B2 | IGFBP2 BIOMARKER | MERCK SHARP & DOHME (US) | 2015-10-28 | — | — | EP | disclosed |
| EP-0437290-B1 | Process for the preparation of 5-oxohexane nitriles and the compound 2,4-dimethyl-5-oxohexane nitrile | DSM NV (NL) | 1998-05-06 | — | — | EP | disclosed |
| EP-0437290-B1 | Process for the preparation of 5-oxohexane nitriles and the compound 2,4-dimethyl-5-oxohexane nitrile | DSM NV (NL) | 1998-05-06 | — | — | EP | disclosed |
| US-5334721-A | Reacting a methyl ketone and an alpha,beta-unsaturated nitrile in the presence of a basic catalyst; preparation of a 2-methyl-3,5-dialkylpyridine; cyclization; dehydrogenation | STAMICARBON B.V. (NL) | 1994-08-02 | — | — | US | disclosed |
| US-5334721-A | Reacting a methyl ketone and an alpha,beta-unsaturated nitrile in the presence of a basic catalyst; preparation of a 2-methyl-3,5-dialkylpyridine; cyclization; dehydrogenation | STAMICARBON B.V. (NL) | 1994-08-02 | — | — | US | disclosed |
| US-5254712-A | Using basic catalyst | STAMICARBON B.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| US-5254712-A | Using basic catalyst | STAMICARBON B.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| US-5254712-A | Using basic catalyst | STAMICARBON B.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| JP-H04253946-A | PRODUCTION OF 5-OXOHEXANENITRILE,2,4-DIMETHYL-5-OXOHEXANENITRILE AND 2,3,5-TRIMETHYLPYRIDINE AND 2-METHYL-3,5-DIALKYLPYRIDINE | STAMICARBON BV | 1992-09-09 | — | — | JP | disclosed |
| WO-1991017979-A1 | PROCESS FOR THE PREPARATION OF 2-N-ACYLAMINOPYRIDINES AND 2-AMINOPYRIDINES FROM 5-OXOALKANENITRILE OXIMES | DSM N.V. (NL) | 1991-11-28 | — | — | WO | disclosed |
| EP-0437290-A1 | Process for the preparation of 5-oxohexane nitriles and the compound 2,4-dimethyl-5-oxohexane nitrile | DSM N.V. (NL) | 1991-07-17 | — | — | EP | disclosed |
| EP-0437290-A1 | Process for the preparation of 5-oxohexane nitriles and the compound 2,4-dimethyl-5-oxohexane nitrile | DSM N.V. (NL) | 1991-07-17 | — | — | EP | disclosed |
| EP-0437290-A1 | Process for the preparation of 5-oxohexane nitriles and the compound 2,4-dimethyl-5-oxohexane nitrile | DSM N.V. (NL) | 1991-07-17 | — | — | EP | disclosed |