Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 17/20 | 0.57 |
| ▸ | ITGAV | P06756 | 17/20 | 0.57 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2492323 | 0.97 | ITGB3 (0.53) | ITGB3ITGAVITGB5MAPTKMT2A | |
| SCHEMBL853742 | 0.92 | ITGB3 (0.65) | ITGB3ITGAVITGB5SLC6A2SLC6A4 | |
| SCHEMBL853110 | 0.85 | ITGB3 (0.51) | ITGB3ITGAVITGB5MAPTKMT2A | |
| SCHEMBL2494146 | 0.83 | ITGB3 (0.51) | ITGB3ITGAVITGB5MAPTKMT2A | |
| SCHEMBL852515 | 0.80 | ITGB3 (0.48) | ITGB3ITGAVITGB5MAPTKMT2A | |
| SCHEMBL861140 | 0.79 | ITGB3 (0.83) | ITGB3ITGAVITGB5 | |
| SCHEMBL852592 | 0.78 | ITGB3 (0.58) | ITGB3ITGAVITGB5 | |
| SCHEMBL861748 | 0.75 | LMNA (0.43) | ITGB3ITGAVITGB5MAPTKMT2A | |
| SCHEMBL854741 | 0.73 | ITGB3 (0.65) | ITGB3ITGAVITGB5 | |
| SCHEMBL860724 | 0.73 | ITGB3 (1.00) | ITGB3ITGAVITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425010-B8 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICALS INC (US) | 2012-03-28 | — | — | EP | disclosed |
| EP-1425010-A4 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2009-07-29 | — | — | EP | disclosed |
| EP-1425010-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-06-09 | — | — | EP | disclosed |
| WO-2002060438-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | WO | disclosed |