Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ACP1 | P24666 | 3/20 | 0.40 |
| ▸ | MOK | Q9UQ07 | 3/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618647 | 0.98 | KDM4E (0.41) | PDE10ADHODHKDM4EALDH1A1GAA | |
| SCHEMBL8616655 | 0.97 | KDM4E (0.40) | PDE10ADHODHKDM4EALDH1A1GAA | |
| SCHEMBL8613259 | 0.95 | PDE10A (0.42) | PDE10ADHODHKDM4EALDH1A1GAA | |
| SCHEMBL8616287 | 0.92 | PDE10A (0.49) | PDE10AACP1MOKTRPV1 | |
| SCHEMBL8614071 | 0.86 | PDE10A (0.40) | PDE10AKDM4EALDH1A1GAAGLA | |
| SCHEMBL8616012 | 0.86 | PDE10A (0.40) | PDE10ADHODHKDM4EALDH1A1ACP1 | |
| SCHEMBL8613965 | 0.85 | PDE10A (0.46) | PDE10ADHODHKDM4EALDH1A1GAA | |
| SCHEMBL8614159 | 0.84 | PDE10A (0.45) | PDE10AKDM4EALDH1A1GAAHPGD | |
| SCHEMBL8619516 | 0.84 | PDE10A (0.44) | PDE10ADHODHKDM4EALDH1A1GAA | |
| SCHEMBL8620892 | 0.83 | HTT (0.47) | KDM4EALDH1A1HPGDACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |