Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | OGG1 | O15527 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14590673 | 0.90 | NOTUM (0.64) | NOTUMKDM4EHRH3ALDH1A1 | |
| SCHEMBL17324776 | 0.80 | HRH3 (0.47) | ROCK1HRH3 | |
| SCHEMBL30852680 | 0.79 | ROCK1 (0.44) | ROCK1KDM4EHRH3ALDH1A1MGLL | |
| SCHEMBL2208006 | 0.78 | NOTUM (0.78) | NOTUMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL8616607 | 0.78 | NOTUM (0.42) | NOTUMKDM4EALDH1A1 | |
| SCHEMBL8619661 | 0.78 | NOTUM (0.47) | NOTUMKDM4EALDH1A1 | |
| SCHEMBL8616507 | 0.78 | NOTUM (0.42) | ROCK1NOTUMKDM4EALDH1A1 | |
| SCHEMBL8613255 | 0.78 | NOTUM (0.42) | NOTUMKDM4EHRH3ALDH1A1SMN1; SMN2 | |
| SCHEMBL20250850 | 0.78 | HRH3 (0.56) | ROCK1KDM4EHRH3ALDH1A1MGLL | |
| SCHEMBL17321532 | 0.77 | HRH3 (0.44) | ROCK1KDM4EHRH3ALDH1A1MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |