Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 7/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619661 | 0.86 | NOTUM (0.47) | NOTUMHTR1DHTR1BHTR2ACYP11B2 | |
| SCHEMBL8613255 | 0.86 | NOTUM (0.42) | NOTUMHTR1DHTR1BHTR2ALMNA | |
| SCHEMBL8616507 | 0.86 | NOTUM (0.42) | NOTUMHTR1DHTR1BHTR2ACYP11B2 | |
| SCHEMBL8612515 | 0.85 | HTR2A (0.41) | NOTUMHTR1DHTR1BHTR2ACYP11B2 | |
| SCHEMBL8614407 | 0.78 | ROCK1 (0.54) | NOTUMKDM4EALDH1A1 | |
| SCHEMBL14590673 | 0.78 | NOTUM (0.64) | NOTUMCYP11B2LMNATP53KDM4E | |
| SCHEMBL8616138 | 0.74 | HTR1D (0.57) | HTR1DHTR1BHTR2AMAPT | |
| SCHEMBL8616709 | 0.73 | HTR2C (0.49) | HTR1DHTR1BHTR2A | |
| SCHEMBL8136268 | 0.69 | NOTUM (0.48) | NOTUMHTR1DHTR1BHTR2ACYP11B2 | |
| SCHEMBL8615260 | 0.69 | NOS3 (0.39) | HTR1BKDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |