Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | CASR | P41180 | 8/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8682786 | 0.77 | NOS1 (0.41) | CASRALDH1A1GAACNR1CNR2 | |
| SCHEMBL5731973 | 0.75 | CNR1 (0.41) | ALDH1A1GAACNR1CNR2RAB9A | |
| SCHEMBL8615796 | 0.72 | HSPA5 (0.34) | HSPA5CNR1CNR2 | |
| SCHEMBL8616899 | 0.70 | CNR1 (0.33) | KDM4ECNR1CNR2ESR1 | |
| SCHEMBL12179226 | 0.69 | NOS1 (0.41) | ALDH1A1GAACNR1CNR2RAB9A | |
| Hydrochloric Acid SCHEMBL8618715 | 0.69 | CNR1 (0.33) | KDM4ECNR1CNR2ESR1 | |
| SCHEMBL8618808 | 0.68 | ALDH1A1 (0.32) | KDM4EALDH1A1CNR1CNR2ESR1 | |
| SCHEMBL5164470 | 0.67 | — | — | |
| SCHEMBL12006685 | 0.67 | CNR1 (0.41) | ALDH1A1GAACNR1CNR2RAB9A | |
| SCHEMBL14777822 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731335-A | NERVOUS SYSTEM DISORDERS; STROKE; ANTIISCHEMIC AGENTS; COGNITION ACTIVATORS | ASTRA AKTIEBOLAG (SE) | 1998-03-24 | — | — | US | disclosed |
| US-5607956-A | TREATMENT OF NEURODEGENERATIVE DISORDERS SUCH AS CEREBRAL ISCHEMIA, ALZHEIMER'S DISEASE | ASTRA AKTIEBOLAG (SE) | 1997-03-04 | — | — | US | disclosed |
| EP-0707584-A1 | NOVEL (1-HETEROAZOLYL-1-HETEROCYCLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS | Astra Aktiebolag (SE) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001979-A1 | NOVEL (1-HETEROAZOLYL-1-HETEROCYCLYL)ALKANE DERIVATIVES AND THEIR USE AS NEUROPROTECTIVE AGENTS | ASTRA AKTIEBOLAG (SE) | 1995-01-19 | — | — | WO | disclosed |