Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 15/20 | 0.47 |
| ▸ | KIT | P10721 | 11/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617925 | 0.83 | MAPK8 (0.46) | CSF1RKIT | |
| SCHEMBL8309890 | 0.80 | EGFR (0.65) | FLT3ABCG2 | |
| SCHEMBL7754110 | 0.72 | EGFR (0.54) | ABCG2 | |
| SCHEMBL8614557 | 0.72 | TP53 (0.57) | CSF1RABCG2 | |
| SCHEMBL360021 | 0.72 | EGFR (0.53) | FLT3 | |
| Hydrochloric Acid SCHEMBL8615582 | 0.70 | EGFR (0.45) | CSF1RKITFLT3 | |
| SCHEMBL13362688 | 0.70 | CDK2 (0.50) | — | |
| SCHEMBL13574015 | 0.70 | TP53 (0.44) | CSF1RKITFLT3 | |
| SCHEMBL2205050 | 0.70 | KDM4E (0.52) | CSF1RABCG2 | |
| SCHEMBL8812882 | 0.69 | PDGFRB (0.57) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |