Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.54 |
| ▸ | RAD52 | P43351 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | UBE2N | P61088 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246693 | 0.86 | ABCG2 (0.58) | EGFRERBB2RAD52TP53MAPT | |
| SCHEMBL7799220 | 0.81 | ABCG2 (0.65) | EGFRERBB2MAPTKDRABCG2 | |
| SCHEMBL7797381 | 0.80 | KDM4E (0.43) | EGFRERBB2RAD52TP53MAPT | |
| SCHEMBL2205050 | 0.80 | KDM4E (0.52) | EGFRERBB2RAD52MAPTMEN1 | |
| SCHEMBL8812882 | 0.79 | PDGFRB (0.57) | EGFRTP53MAPTPOLBKDR | |
| SCHEMBL7801861 | 0.79 | KDM4E (0.55) | EGFRTP53MAPTPOLBKDR | |
| SCHEMBL360021 | 0.79 | EGFR (0.53) | EGFRTP53MAPTPOLBKDR | |
| SCHEMBL7757002 | 0.79 | PDGFRB (0.59) | EGFRMAPTKDRKDM4EALDH1A1 | |
| SCHEMBL27565491 | 0.78 | KDM4E (0.49) | RAD52TP53MAPTPOLBMEN1 | |
| SCHEMBL7766729 | 0.78 | MEN1 (0.46) | EGFRERBB2TP53MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999061428-A9 | QUINAZOLINES FOR TREATING BRAIN TUMOR | PARKER HUGHES INST (US) | 2001-10-04 | — | — | WO | disclosed |
| WO-2001035952-A2 | RADIOSENSITIZATION OF HUMAN GLIOBLASTOMA CELLS BY QUINAZOLINE COMPOUNDS | PARKER HUGUES INSTITUTE (US) | 2001-05-25 | — | — | WO | disclosed |