Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3633716 | 0.84 | CYP1A2 (0.47) | PTGS2MAPTCYP2D6 | |
| SCHEMBL10728103 | 0.83 | PTGS2 (0.48) | PTGS2TRPA1FAAHGPR88APAF1 | |
| SCHEMBL11684343 | 0.82 | ALDH1A1 (0.47) | PTGS2MAPTFAAHAPAF1 | |
| SCHEMBL508956 | 0.81 | PTGS2 (0.50) | PTGS2MAPTFAAHAPAF1CYP2D6 | |
| SCHEMBL9074425 | 0.81 | ALDH1A1 (0.55) | — | |
| SCHEMBL27666438 | 0.81 | NPSR1 (0.50) | PTGS2GPR88 | |
| SCHEMBL3410010 | 0.79 | ALDH1A1 (0.50) | PTGS2TRPA1FAAHCYP2D6 | |
| SCHEMBL13389325 | 0.79 | ALDH1A1 (0.50) | PTGS2TRPA1FAAHCYP2D6 | |
| Ethylene Glycol SCHEMBL29068309 | 0.79 | PTGS2 (0.64) | PTGS2MAPTAPAF1CYP2D6 | |
| SCHEMBL7641669 | 0.78 | ASAH1 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2192932-B1 | OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS | ALCON INC (CH) | 2011-05-04 | — | — | EP | disclosed |
| US-7888403-B2 | soft foldable intraocular lenses with no glistenings or vacuoles when stored in water; monofunctional phenyl or alkylphenyl acrylate or acrylamide and difunctional acrylate or acrylamide monomers; a di- or tri-block acrylic macromer | ALCON, INC. (CH) | 2011-02-15 | — | — | US | disclosed |
| WO-2009046232-A1 | OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS | ALCON, INC. (CH) | 2009-04-09 | — | — | WO | disclosed |
| US-20090093592-A1 | OPHTHALMIC AND OTORHINOLARYNGOLOGICAL DEVICE MATERIALS | ALCON, INC. (CH) | 2009-04-09 | — | — | US | disclosed |
| EP-0863895-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997018203-A1 | PIPERAZINE, PIPERIDINE AND TETRAHYDROPYRIDINE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1997-05-22 | — | — | WO | disclosed |