Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL6 | P41182 | 4/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306865 | 0.80 | EGFR (0.58) | EPHB4MAPTMEN1KMT2ALMNA | |
| SCHEMBL2205050 | 0.77 | KDM4E (0.52) | IGF1REPHB4MAPTGAASTK17B | |
| SCHEMBL8618527 | 0.73 | ERBB2 (0.59) | IGF1RSTK17BSTK17A | |
| SCHEMBL7801861 | 0.73 | KDM4E (0.55) | MAPTSTK17ABRAFKDM4EALDH1A1 | |
| SCHEMBL8614905 | 0.71 | BRD4 (0.44) | BCL6IGF1REPHB4MAPTGAA | |
| SCHEMBL28221880 | 0.70 | PDGFRB (0.64) | MAPTMEN1KMT2ALMNABRAF | |
| SCHEMBL8309503 | 0.69 | POLB (0.45) | MAPTGAANPC1RAB9AALDH1A1 | |
| Hydrochloric Acid SCHEMBL8615582 | 0.69 | EGFR (0.45) | BCL6IGF1REPHB4MAPTGAA | |
| SCHEMBL8305217 | 0.69 | EGFR (0.58) | FLT3ABCG2KDR | |
| SCHEMBL8812882 | 0.68 | PDGFRB (0.57) | MAPTGAABRAFKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |