Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | F2RL1 | P55085 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | F7 | P08709 | 1/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308037 | 0.82 | ALDH1A1 (0.35) | NPC1RAB9AALDH1A1GAAADRA2A | |
| SCHEMBL2103199 | 0.72 | CSNK2A1 (0.61) | POLBCSNK2A1KMOALDH1A1GAA | |
| SCHEMBL8306865 | 0.72 | EGFR (0.58) | MAPK1ALDH1A1CYP3A4CYP1A2CYP2D6 | |
| SCHEMBL12173109 | 0.71 | RORC (0.58) | POLBMAPK1CSNK2A1ALDH1A1GAA | |
| SCHEMBL30729908 | 0.70 | POLB (0.51) | POLBMAPK1CSNK2A1NPC1RAB9A | |
| SCHEMBL27096999 | 0.70 | POLB (0.51) | POLBMAPK1CSNK2A1NPC1RAB9A | |
| SCHEMBL697868 | 0.69 | ADRA2A (0.48) | MAPK1KMOALDH1A1ADRA2AADRA2B | |
| SCHEMBL10502196 | 0.68 | FPR2 (0.34) | ADRA2AADRA2BADRA2CF2RL1 | |
| SCHEMBL11189892 | 0.68 | ADRA2A (0.40) | POLBMAPK1ALDH1A1GAAADRA2A | |
| SCHEMBL4063139 | 0.67 | ALDH1A1 (0.41) | POLBNPC1RAB9AALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |