Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 5/20 | 0.41 |
| ▸ | FDPS | P14324 | 5/20 | 0.39 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 4/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.35 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.34 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.33 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.33 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.33 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.33 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.33 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5682842 | 0.78 | SMPD1 (0.40) | SMPD1FDPSGGPS1S1PR4S1PR1 | |
| SCHEMBL1764394 | 0.76 | LMNA (0.34) | — | |
| SCHEMBL16937307 | 0.76 | LMNA (0.34) | — | |
| SCHEMBL14639283 | 0.75 | LMNA (0.32) | — | |
| SCHEMBL768930 | 0.75 | LMNA (0.32) | — | |
| SCHEMBL14639329 | 0.75 | LMNA (0.32) | — | |
| Triphosphate SCHEMBL30619686 | 0.69 | SMPD1 (0.42) | SMPD1FDPSGGPS1PTPN1LPAR1 | |
| SCHEMBL13730862 | 0.68 | CYP2D6 (0.41) | SMPD1FDPSS1PR4S1PR1S1PR3 | |
| SCHEMBL8520599 | 0.68 | CYP2D6 (0.34) | FDPSGGPS1 | |
| SCHEMBL17766210 | 0.68 | FDPS (0.35) | SMPD1FDPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0466838-B1 | NOVEL LIPID A DERIVATIVES AND USES THEREFOR | WISCONSIN ALUMNI RES FOUND (US) | 1998-04-01 | — | — | EP | disclosed |
| EP-0466838-A4 | — | WISCONSIN ALUMNI RES FOUND (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5158939-A | Administering a nontoxic lipopolysaccharide from rhodopseudomonas which negate the inhibitory effects of thymus derived T suppressor cells | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0466838-A1 | NOVEL LIPID A DERIVATIVES AND USES THEREFOR | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1992-01-22 | — | — | EP | disclosed |
| US-5041427-A | Protection Against Gramnegative Endotoxin | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1991-08-20 | — | — | US | disclosed |
| WO-1991001134-A1 | NOVEL LIPID A DERIVATIVES AND USES THEREFOR | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1991-02-07 | — | — | WO | disclosed |