Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7607718 | 1.00 | MCHR1 (0.47) | MCHR1ALDH1A1CA12CA1CA2 | |
| SCHEMBL8685457 | 0.87 | MCHR1 (0.50) | MCHR1ALDH1A1DRD2DRD3NOTUM | |
| SCHEMBL8661980 | 0.85 | ALDH1A1 (0.48) | MCHR1ALDH1A1CA12CA1CA2 | |
| SCHEMBL6203746 | 0.82 | NOTUM (0.51) | MCHR1ALDH1A1CA12CA1CA2 | |
| SCHEMBL7613749 | 0.81 | MCHR1 (0.50) | MCHR1ALDH1A1CA12CA1CA2 | |
| SCHEMBL8096814 | 0.79 | CA12 (0.47) | MCHR1ALDH1A1CA12CA1CA2 | |
| SCHEMBL8103747 | 0.79 | MCHR1 (0.48) | MCHR1ALDH1A1CA12CA1CA2 | |
| SCHEMBL8089857 | 0.78 | NPSR1 (0.47) | MCHR1CA12CA1CA2CA9 | |
| SCHEMBL5827041 | 0.76 | CA12 (0.53) | MCHR1CA12CA1CA2CA9 | |
| SCHEMBL1010136 | 0.75 | ALDH1A1 (0.55) | MCHR1ALDH1A1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863872-A1 | PREPARATION OF CHIRAL 3-HYDROXY-2-PYRROLIDINONE DERIVATIVES | ZENECA LIMITED (GB) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019920-A1 | PREPARATION OF CHIRAL 3-HYDROXY-2-PYRROLIDINONE DERIVATIVES | ZENECA LIMITED (GB) | 1997-06-05 | — | — | WO | disclosed |