Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619756 | 0.92 | PLA2G2A (0.54) | PDE10APLA2G2AKDM4EALDH1A1NPC1 | |
| SCHEMBL8618688 | 0.91 | PLA2G2A (0.53) | PDE10APLA2G2AKDM4EALDH1A1NPC1 | |
| SCHEMBL8619445 | 0.87 | PLA2G2A (0.46) | PDE10APLA2G2AKDM4EALDH1A1NPC1 | |
| SCHEMBL8617940 | 0.85 | PLA2G2A (0.48) | PDE10APLA2G2AKDM4EALDH1A1NPC1 | |
| SCHEMBL8616490 | 0.84 | LMNA (0.45) | PDE10APLA2G2AKDM4EALDH1A1NPC1 | |
| SCHEMBL8616024 | 0.84 | ACP1 (0.46) | PDE10APLA2G2AKDM4EALDH1A1NPC1 | |
| SCHEMBL8620711 | 0.83 | ACP1 (0.60) | KDM4EALDH1A1LMNAHPGDMAPT | |
| SCHEMBL8617062 | 0.83 | PDE10A (0.44) | PDE10APLA2G2AKDM4EALDH1A1NPC1 | |
| SCHEMBL8617680 | 0.82 | TACR3 (0.35) | PDE10APLA2G2AKDM4EALDH1A1LMNA | |
| SCHEMBL8617753 | 0.81 | ACP1 (0.51) | PDE10AKDM4ELMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |