Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 3/20 | 1.00 |
| ▸ | DYRK1A | Q13627 | 3/20 | 1.00 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 1.00 |
| ▸ | CSNK2B | P67870 | 2/20 | 1.00 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 1.00 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 1.00 |
| ▸ | DYRK2 | Q92630 | 1/20 | 1.00 |
| ▸ | PIM1 | P11309 | 3/20 | 0.69 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.69 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 2/20 | 0.69 |
| ▸ | RAB9A | P51151 | 2/20 | 0.69 |
| ▸ | GSK3B | P49841 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | METAP1 | P53582 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ESR1 | P03372 | 2/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7466029 | 0.83 | CSNK2A1 (0.71) | CLK1DYRK1ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL1247708 | 0.81 | PIM1 (1.00) | CLK1DYRK1ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL2546911 | 0.81 | PIM1 (1.00) | CLK1DYRK1ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL1247705 | 0.81 | PIM1 (1.00) | CLK1DYRK1ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7519991 | 0.79 | CSNK2A2 (0.65) | CLK1DYRK1ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL4156417 | 0.79 | CSNK2A2 (0.65) | CLK1DYRK1ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL5672827 | 0.78 | PIM1 (0.72) | CLK1DYRK1ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL2684656 | 0.78 | RAB9A (0.74) | CLK1DYRK1ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL5509142 | 0.78 | PIM1 (0.91) | CLK1DYRK1ACSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL8272567 | 0.78 | PIM1 (0.91) | CLK1DYRK1ACSNK2A2CSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |
| EP-0612729-B1 | Pyridine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-04-23 | — | — | EP | disclosed |
| US-5561147-A | ANTIINFLAMMATORY AGENT, ANTIPYRETIC, ANALGESICS, ANTIALLERGENS, IMMUNOSUPPRESSANTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-10-01 | — | — | US | disclosed |
| US-5457106-A | Antiinflammatory agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-10-10 | — | — | US | disclosed |
| US-5389658-A | Administering as antipyretic, antiinflammatory, analgesic, antiallergic, or immunosupressive agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-02-14 | — | — | US | disclosed |
| EP-0612729-A2 | Pyridine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1994-08-31 | — | — | EP | disclosed |
| US-5246948-A | Antiinflammatory, antipyretic, analgesic, antiallergic, immunosupressing or immunomodulating activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-09-21 | — | — | US | disclosed |
| EP-0522606-A2 | Pyridine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-13 | — | — | EP | disclosed |