Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.62 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.62 |
| ▸ | CLK1 | P49759 | 4/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 4/20 | 0.52 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 2/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 2/20 | 0.52 |
| ▸ | PRKACG | P22612 | 2/20 | 0.52 |
| ▸ | PRKACB | P22694 | 2/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.52 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.52 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.52 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.52 |
| ▸ | CSNK1G1 | Q9HCP0 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nortopsentin B SCHEMBL8615899 | 1.00 | ADRA1A (0.62) | ADRA1AADRA1BCLK1CDK5CDK5R1 | |
| Nortopsentin C SCHEMBL29489919 | 1.00 | ADRA1A (0.62) | ADRA1AADRA1BCLK1CDK5CDK5R1 | |
| Nortopsentin B SCHEMBL29489896 | 1.00 | ADRA1A (0.62) | ADRA1AADRA1BCLK1CDK5CDK5R1 | |
| Nortopsentin A SCHEMBL29489899 | 0.93 | CLK1 (0.58) | ADRA1AADRA1BCLK1CDK5CDK5R1 | |
| Nortopsentin A SCHEMBL8616377 | 0.93 | CLK1 (0.58) | ADRA1AADRA1BCLK1CDK5CDK5R1 | |
| Nortopsentin D SCHEMBL29489921 | 0.87 | PDGFRB (0.62) | CLK1CDK5CDK5R1GSK3BMEN1 | |
| SCHEMBL5443201 | 0.82 | ADRA1A (0.65) | ADRA1AADRA1BCLK1CDK5CDK5R1 | |
| SCHEMBL25034159 | 0.79 | MEN1 (0.73) | ADRA1AADRA1BCLK1CDK5CDK5R1 | |
| Bromodeoxytopsentin SCHEMBL17537615 | 0.78 | ADRA1A (0.53) | ADRA1AADRA1BCLK1CDK5CDK5R1 | |
| SCHEMBL14023555 | 0.75 | ADRA1A (0.55) | ADRA1AADRA1BMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686154-B1 | NOVEL USE AS ANTI-INFLAMMATORY AGENTS FOR BIS-HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF | HARBOR BRANCH OCEANOGRAPHIC (US) | 1998-04-22 | — | — | EP | claimed |