SCHEMBL8616017

SCHEMBL8616017

O=C(c1ccccc1)N(CCCSc1ccccn1)Cc1cccs1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
KMT2A Q03164 3/20 0.47
ALDH1A1 P00352 3/20 0.47
MAPT P10636 2/20 0.47
MEN1 O00255 2/20 0.47
USP2 O75604 1/20 0.47
TSHR P16473 1/20 0.41
TRPM8 Q7Z2W7 4/20 0.41
TDP1 Q9NUW8 2/20 0.41
POLB P06746 2/20 0.41
CYP1A2 P05177 1/20 0.38
CHRM2 P08172 1/20 0.38
CHRM5 P08912 1/20 0.38
ADRA2A P08913 1/20 0.38
CYP2D6 P10635 1/20 0.38
CHRM1 P11229 1/20 0.38
CYP2C9 P11712 1/20 0.38
ADRA2B P18089 1/20 0.38
NFKB1 P19838 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8620508 0.99 HDAC1 (0.47) HDAC1HDAC6KMT2AALDH1A1MAPT
SCHEMBL8618984 0.85 ALDH1A1 (0.54) HDAC1HDAC6KMT2AALDH1A1MAPT
SCHEMBL8967158 0.85 HDAC1 (0.49) HDAC1HDAC6KMT2AALDH1A1MAPT
Hydrochloric Acid SCHEMBL8620325 0.84 ALDH1A1 (0.53) HDAC1HDAC6KMT2AALDH1A1MAPT
Hydrochloric Acid SCHEMBL8966348 0.84 HDAC1 (0.48) HDAC1HDAC6KMT2AALDH1A1MAPT
SCHEMBL8614975 0.83 ALDH1A1 (0.52) HDAC1KMT2AALDH1A1MAPTTSHR
Hydrochloric Acid SCHEMBL8615124 0.82 ALDH1A1 (0.51) HDAC1KMT2AALDH1A1MAPTTSHR
SCHEMBL6127323 0.80 HDAC1 (0.61) HDAC1HDAC6KMT2AALDH1A1MAPT
SCHEMBL8614121 0.78 ALDH1A1 (0.57) HDAC1HDAC6KMT2AALDH1A1MAPT
SCHEMBL6123024 0.76 HDAC1 (0.72) HDAC1HDAC6KMT2AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5767121-A ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-06-16 US disclosed