Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | G6PD | P11413 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | CCNK | O75909 | 1/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616025 | 0.85 | DHODH (0.62) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8615207 | 0.83 | DHODH (0.60) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8619026 | 0.81 | DHODH (0.62) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8619384 | 0.80 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8615901 | 0.80 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8616015 | 0.80 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL9160491 | 0.80 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL9017547 | 0.80 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL8615204 | 0.80 | DHODH (0.61) | DHODHKMT2AMEN1G6PDCACNA1B | |
| SCHEMBL18118641 | 0.76 | DHODH (0.70) | DHODHKMT2AMEN1G6PDCACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632017-B1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-05-06 | — | — | EP | disclosed |
| EP-0632017-A1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-01-04 | — | — | EP | disclosed |