Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.40 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 3/20 | 0.39 |
| ▸ | ACP1 | P24666 | 2/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619429 | 0.89 | ABCG2 (0.44) | ABCB1ABCG2ABCC1TACR3ACP1 | |
| SCHEMBL8613674 | 0.83 | TRPV1 (0.43) | ABCB1ABCG2ABCC1TACR3ACP1 | |
| SCHEMBL8615808 | 0.83 | KDM4E (0.50) | ABCB1ABCG2ABCC1TACR3ACP1 | |
| SCHEMBL8617739 | 0.82 | ALDH1A1 (0.47) | ABCB1ABCG2ABCC1TACR3ACP1 | |
| SCHEMBL8617753 | 0.82 | ACP1 (0.51) | ABCB1ABCG2ABCC1ACP1 | |
| SCHEMBL8619039 | 0.81 | DHODH (0.46) | ABCB1ABCG2ABCC1TACR3ACP1 | |
| SCHEMBL8614310 | 0.81 | TACR3 (0.44) | ABCB1ABCG2ABCC1TACR3ACP1 | |
| SCHEMBL8615210 | 0.81 | TACR3 (0.44) | ABCB1ABCG2ABCC1TACR3ACP1 | |
| SCHEMBL8619415 | 0.80 | ABCB1 (0.47) | ABCB1ABCG2ABCC1TACR3ACP1 | |
| SCHEMBL8615938 | 0.80 | TACR3 (0.41) | ABCB1ABCG2ABCC1TACR3ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |