Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 4/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6998722 | 0.85 | ADORA2B (0.43) | HDAC2HDAC3HDAC1ADORA2BADORA3 | |
| SCHEMBL7001806 | 0.77 | RXFP1 (0.56) | HDAC1RXFP1CA1CA2CA9 | |
| SCHEMBL6990668 | 0.74 | MAPT (0.52) | AAK1ADORA2AADORA1CCNCCDK8 | |
| SCHEMBL8616595 | 0.72 | LMNA (0.46) | — | |
| SCHEMBL26921845 | 0.69 | RXFP1 (0.48) | HDAC2HDAC3HDAC1RXFP1CA1 | |
| SCHEMBL2429572 | 0.68 | RXFP1 (0.53) | HDAC1RXFP1CA1CA2CA9 | |
| SCHEMBL8118565 | 0.67 | JAK2 (0.44) | HDAC2HDAC3HDAC1KDM4ENTRK1 | |
| SCHEMBL11279567 | 0.67 | HDAC2 (0.74) | HDAC2HDAC3HDAC1AAK1 | |
| SCHEMBL8118373 | 0.67 | RXFP1 (0.55) | RXFP1ADORA2BADORA3ADORA2AADORA1 | |
| SCHEMBL16371520 | 0.67 | NPC1 (0.51) | HDAC2HDAC3HDAC1RXFP1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |