Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.45 |
| ▸ | ITGAV | P06756 | 16/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 8/20 | 0.45 |
| ▸ | ITGB5 | P18084 | 4/20 | 0.45 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.45 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.42 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL852486 | 0.81 | MTNR1A (0.48) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL853602 | 0.80 | ITGB3 (0.52) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL852896 | 0.79 | ITGB3 (0.51) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL852895 | 0.78 | MTNR1A (0.46) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL853409 | 0.74 | MTNR1A (0.52) | — | |
| SCHEMBL853853 | 0.74 | MTNR1A (0.51) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL853408 | 0.73 | ITGB3 (0.49) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL853852 | 0.72 | ITGB3 (0.50) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| SCHEMBL853666 | 0.71 | KDM4E (0.56) | ITGB3ITGAVITGB1ITGB5ITGB6 | |
| Ammonia Solution, Strong SCHEMBL853394 | 0.70 | KDM4E (0.55) | ITGB3ITGAVITGB1ITGB5ITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425010-B8 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | JANSSEN PHARMACEUTICALS INC (US) | 2012-03-28 | — | — | EP | claimed |
| EP-1425010-A4 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | ORTHO MCNEIL PHARM INC (US) | 2009-07-29 | — | — | EP | claimed |
| EP-1425010-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2004-06-09 | — | — | EP | claimed |
| WO-2002060438-A1 | SUBSTITUTED INDOLES AND THEIR USE AS INTEGRIN ANTAGONISTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2002-08-08 | — | — | WO | claimed |