Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 8/20 | 0.48 |
| ▸ | EGFR | P00533 | 8/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618248 | 0.86 | EGFR (0.52) | ERBB2EGFRLCKERBB4MAPK1 | |
| SCHEMBL8615603 | 0.82 | EGFR (0.43) | ERBB2EGFRLCKERBB4MAPK1 | |
| SCHEMBL8616130 | 0.80 | EGFR (0.52) | ERBB2EGFRLCKERBB4MAPT | |
| SCHEMBL8309481 | 0.79 | EGFR (0.50) | ERBB2EGFRLCKERBB4MAPT | |
| SCHEMBL8309434 | 0.72 | EGFR (0.66) | ERBB2EGFRLCKERBB4ABCG2 | |
| SCHEMBL8306485 | 0.72 | EGFR (0.53) | ERBB2EGFRLCKERBB4MAPT | |
| SCHEMBL8617057 | 0.72 | EGFR (0.56) | ERBB2EGFRLCKERBB4MAPK1 | |
| SCHEMBL8307584 | 0.71 | ERBB2 (0.68) | ERBB2EGFRLCKERBB4AURKA | |
| SCHEMBL8621541 | 0.69 | EGFR (0.55) | ERBB2EGFRLCKERBB4MAPK1 | |
| SCHEMBL8306919 | 0.69 | KDR (0.65) | ERBB2EGFRERBB4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |