Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.81 |
| ▸ | DHODH | Q02127 | 2/20 | 0.61 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | CCR6 | P51684 | 1/20 | 0.57 |
| ▸ | ACACA | Q13085 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616292 | 0.90 | PDE10A (1.00) | PDE10ADHODHALDH1A1HPGDCCR6 | |
| SCHEMBL8617709 | 0.83 | PDE10A (0.69) | PDE10ADHODHALDH1A1HPGDCCR6 | |
| SCHEMBL2576382 | 0.81 | KDM4E (0.76) | PDE10ADHODHPLA2G2AALDH1A1HPGD | |
| SCHEMBL30690053 | 0.81 | PLA2G2A (0.73) | PDE10ADHODHPLA2G2AALDH1A1HPGD | |
| SCHEMBL6659920 | 0.80 | TACR3 (0.74) | PDE10AALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8617941 | 0.79 | PDE10A (0.64) | PDE10ADHODHALDH1A1HPGDACACA | |
| SCHEMBL11395164 | 0.78 | PDE10A (0.67) | PDE10AALDH1A1HPGDACACAKDM4E | |
| SCHEMBL3902043 | 0.78 | DHODH (0.62) | PDE10ADHODHPLA2G2AALDH1A1HPGD | |
| SCHEMBL7826492 | 0.77 | PDE10A (0.77) | PDE10ADHODHALDH1A1HPGDCCR6 | |
| SCHEMBL8876443 | 0.77 | PDE10A (0.52) | PDE10ADHODHPLA2G2AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |