SCHEMBL8617042

SCHEMBL8617042

Brc1ccccc1-c1nc2ccccc2s1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.64
NPC1 O15118 9/20 0.64
RAB9A P51151 9/20 0.64
ALDH1A1 P00352 7/20 0.64
MAPT P10636 7/20 0.64
SMN1; SMN2 Q16637 5/20 0.64
L3MBTL1 Q9Y468 4/20 0.64
MEN1 O00255 4/20 0.64
KMT2A Q03164 4/20 0.64
GAA P10253 4/20 0.64
TDP1 Q9NUW8 2/20 0.64
HSD17B10 Q99714 3/20 0.57
NPSR1 Q6W5P4 2/20 0.57
TP53 P04637 2/20 0.57
HPGD P15428 1/20 0.57
PPARG P37231 1/20 0.57
NCOA2 Q15596 1/20 0.57
NCOA1 Q15788 1/20 0.57
RXFP1 Q9HBX9 1/20 0.57
NCOA3 Q9Y6Q9 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30353950 1.00 KDM4E (0.64) KDM4ENPC1RAB9AALDH1A1MAPT
SCHEMBL28961171 0.86 RAB9A (0.61) KDM4ENPC1RAB9AALDH1A1MAPT
SCHEMBL231307 0.86 KDM4E (0.75) KDM4ENPC1RAB9AALDH1A1MAPT
SCHEMBL31336575 0.85 RAB9A (0.63) KDM4ENPC1RAB9AALDH1A1MAPT
SCHEMBL5973870 0.85 RAB9A (0.63) KDM4ENPC1RAB9AALDH1A1MAPT
SCHEMBL12854008 0.84 KDM4E (0.72) KDM4ENPC1RAB9AALDH1A1MAPT
SCHEMBL2481443 0.83 KDM4E (0.56) KDM4ENPC1RAB9AALDH1A1MAPT
SCHEMBL3004574 0.82 KDM4E (0.56) KDM4ENPC1RAB9AALDH1A1MAPT
SCHEMBL11224071 0.80 MAPT (0.52) KDM4ENPC1RAB9AALDH1A1MAPT
SCHEMBL28015728 0.80 KDM4E (0.43) KDM4ENPC1RAB9AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113387819-B Phenanthrene compound, preparation method and application thereof, and organic electroluminescent device 武汉尚赛光电科技有限公司 2023-05-19 CN disclosed
CN-113387819-A Phenanthrene compound, preparation method and application thereof, and organic electroluminescent device 武汉尚赛光电科技有限公司 2021-09-14 CN disclosed
CN-109338402-A A kind of method of electro-catalysis benzo thioamide analog compound synthesis benzothiazole in water 福建医科大学 2019-02-15 CN disclosed
CN-109293599-A A kind of method of microwave radiation benzo thioamide analog compound synthesis benzothiazole in water phase 福建医科大学 2019-02-01 CN disclosed
CN-102936250-B Fused bicyclic mtor inhibitors OSI PHARM INC 2014-07-09 CN disclosed
US-8697872-B2 Boron compounds and uses thereof QUEEN'S UNIVERSITY AT KINGSTON (CA) 2014-04-15 US disclosed
US-20120253044-A1 Boron Compounds and Uses Thereof WANG, SUNING (CA) 2012-10-04 US disclosed
US-5719171-A INSECTICIDES; MITICIDES; NEMATOCIDES; FUNGICIDES BASF AKTIENGESELLSCHAFT (DE) 1998-02-17 US disclosed
US-5594020-A FUNGICIDE BASF AKTIENGESELLSCHAFT (DE) 1997-01-14 US disclosed
EP-0621277-A2 Diarylderivatives and their use for the protection of plants BASF Aktiengesellschaft (DE) 1994-10-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120253044-A1 Boron Compounds and Uses Thereof BRI3BP, BRSK1, BROX KDM4E 1051/4885NPC1 4155/4885RAB9A 1830/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.