SCHEMBL8617542

SCHEMBL8617542

Cc1c[nH]c(SCc2ccccc2-n2ccnc2)n1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR5A P47898 1/20 0.42
IDO1 P14902 1/20 0.40
CYP3A4 P08684 5/20 0.37
CYP1A2 P05177 4/20 0.37
CYP2D6 P10635 4/20 0.37
CYP2C19 P33261 4/20 0.37
CYP2C9 P11712 3/20 0.37
KMT2A Q03164 3/20 0.37
TDP1 Q9NUW8 3/20 0.37
ALDH1A1 P00352 2/20 0.37
MEN1 O00255 2/20 0.37
LMNA P02545 2/20 0.37
MAPT P10636 1/20 0.37
MAPK1 P28482 1/20 0.37
PMP22 Q01453 1/20 0.37
CYP11B1 P15538 3/20 0.37
CYP11B2 P19099 3/20 0.37
CYP19A1 P11511 2/20 0.37
PDE2A O00408 1/20 0.36
MPO P05164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8619287 0.75 IDO1 (0.51) HTR5AIDO1CYP3A4CYP1A2CYP2D6
SCHEMBL8617539 0.72 ELANE (0.58) HTR5AIDO1CYP3A4CYP1A2CYP2D6
SCHEMBL3228422 0.71 IDO1 (0.58) HTR5AIDO1CYP3A4CYP1A2CYP2D6
SCHEMBL9011940 0.70 POLB (0.40) KMT2ATDP1ALDH1A1LMNAPOLB
SCHEMBL26731495 0.68 IDO1 (0.53) HTR5AIDO1CYP3A4CYP1A2CYP2D6
SCHEMBL8436958 0.67 IDO1 (0.61) HTR5AIDO1CYP3A4CYP1A2CYP2D6
SCHEMBL2463222 0.67 IDO1 (0.56) HTR5AIDO1CYP3A4CYP1A2CYP2D6
SCHEMBL26728947 0.67 IDO1 (0.51) HTR5AIDO1CYP3A4CYP1A2CYP2D6
SCHEMBL8619289 0.66 IDO1 (0.47) HTR5AIDO1CYP3A4CYP1A2CYP2D6
SCHEMBL8588747 0.66 IDO1 (0.48) HTR5AIDO1CYP3A4CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0857171-A2 IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 1998-08-12 EP disclosed
WO-1997015555-A2 IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS SCHERING AKTIENGESELLSCHAFT (DE) 1997-05-01 WO disclosed