Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | HTR5A | P47898 | 1/20 | 0.42 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8617541 | 0.81 | HTR5A (0.40) | ELANEKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8619287 | 0.78 | IDO1 (0.51) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3228422 | 0.74 | IDO1 (0.58) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL9012435 | 0.73 | ELANE (0.53) | ELANEKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8617542 | 0.72 | HTR5A (0.42) | KMT2APOLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL26731495 | 0.70 | IDO1 (0.53) | KMT2APOLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8436958 | 0.70 | IDO1 (0.61) | KMT2APOLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2463222 | 0.70 | IDO1 (0.56) | KMT2APOLBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL26728947 | 0.69 | IDO1 (0.51) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8619289 | 0.69 | IDO1 (0.47) | KMT2ACYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0857171-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-08-12 | — | — | EP | disclosed |
| WO-1997015555-A2 | IMIDAZOLE DERIVATIVES AND THE USE THEREOF AS NITROGEN MONOXIDE SYNTHASE INHIBITORS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-05-01 | — | — | WO | disclosed |