Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 3/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18158116 | 0.83 | KDM4E (0.54) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL26033476 | 0.78 | TAS1R3 (0.49) | NPC1RAB9AKMT2AGAASMN1; SMN2 | |
| SCHEMBL8617518 | 0.75 | KMT2A (0.52) | NPC1RAB9AKMT2AGAASMN1; SMN2 | |
| SCHEMBL22929181 | 0.74 | EPHX2 (0.63) | KMT2ASMN1; SMN2ALDH1A1LMNAALOX15 | |
| SCHEMBL30044824 | 0.73 | KDM4E (0.56) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL8621053 | 0.73 | SMN1; SMN2 (0.57) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL22618848 | 0.72 | KDM4E (0.52) | NPC1RAB9AKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL20988037 | 0.72 | KDM4E (0.59) | NPC1RAB9ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8967581 | 0.71 | SMN1; SMN2 (0.62) | KMT2ASMN1; SMN2ALDH1A1ALOX15MEN1 | |
| SCHEMBL8130992 | 0.71 | KDM4E (0.52) | NPC1RAB9AKMT2AGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |