SCHEMBL8617684

SCHEMBL8617684

COc1cccc(C(O)CN(C)C)c1OCC=C(C)C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 1/20 0.44
ALOX5 P09917 1/20 0.40
ALDH1A1 P00352 2/20 0.39
MGAM O43451 2/20 0.38
GAA P10253 2/20 0.38
SI P14410 2/20 0.38
MGAM2 Q2M2H8 2/20 0.38
MAPT P10636 2/20 0.37
KDM4E B2RXH2 1/20 0.37
CYP3A4 P08684 1/20 0.37
CYP2D6 P10635 1/20 0.37
CYP2C9 P11712 1/20 0.37
CASP1 P29466 1/20 0.37
CYP2C19 P33261 1/20 0.37
CASP7 P55210 1/20 0.37
HSD17B10 Q99714 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.36
TRPA1 O75762 1/20 0.35
MTNR1A P48039 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8619187 0.86 AOC3 (0.45) AOC3ALDH1A1MGAMGAASI
SCHEMBL8619073 0.78 AOC3 (0.49) AOC3ALDH1A1MAPTKDM4ESMN1; SMN2
SCHEMBL9172201 0.74 AOC3 (0.46) AOC3ALDH1A1MAPTSMN1; SMN2
SCHEMBL4598936 0.70 TLR2 (0.55) ALOX5ALDH1A1MGAMGAASI
SCHEMBL8619658 0.70 AOC3 (0.40) AOC3ALOX5ALDH1A1CYP2D6
SCHEMBL8619520 0.69 ALDH1A1 (0.40) AOC3ALDH1A1KDM4E
SCHEMBL8618802 0.69 AOC3 (0.39) AOC3ALDH1A1KDM4ECYP2D6
SCHEMBL8619983 0.69 AOC3 (0.39) AOC3ALDH1A1MAPTCYP2D6
SCHEMBL791960 0.68 SMN1; SMN2 (0.55) ALOX5HSD17B10SMN1; SMN2TRPA1MTNR1A
SCHEMBL12846692 0.66 ALDH1A1 (0.47) AOC3ALOX5ALDH1A1MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0651735-B1 PHARMACOLOGICALLY ACTIVE ALPHA-(TERTIARY-AMINOMETHYL)-PHENYLMETHANOL DERIVATIVES PHARMACIA & UPJOHN AB (SE) 1998-05-20 EP disclosed
US-5527821-A FOR TREATMENT OF URINARY INCONTINENCE PHARMACIA AB (SE) 1996-06-18 US disclosed
EP-0651735-A1 PHARMACOLOGICALLY ACTIVE ALPHA-(TERTIARY-AMINOMETHYL)-PHENYLMETHANOL DERIVATIVES Pharmacia & Upjohn Aktiebolag (SE) 1995-05-10 EP disclosed
WO-1994002442-A1 PHARMACOLOGICALLY ACTIVE α-[TERTIARY-AMINOMETHYL]-BENZENEMETHANOL DERIVATIVES PHARMACIA AB (SE) 1994-02-03 WO disclosed