Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 8/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | TACR3 | P29371 | 2/20 | 0.46 |
| ▸ | KLK7 | P49862 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614773 | 0.95 | ALDH1A1 (0.53) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL8617196 | 0.88 | ALDH1A1 (0.54) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL8617999 | 0.84 | DHODH (0.57) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL8614851 | 0.83 | MEN1 (0.67) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL8620865 | 0.82 | TACR3 (0.46) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL8614314 | 0.82 | KMT2A (0.65) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL8614339 | 0.81 | CYP3A4 (0.54) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL8617790 | 0.81 | KDM4E (0.54) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL8617116 | 0.81 | ALDH1A1 (0.56) | ALDH1A1KDM4ESMN1; SMN2LMNAGAA | |
| SCHEMBL8617743 | 0.81 | CYP3A4 (0.65) | ALDH1A1KDM4ESMN1; SMN2LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0726254-B1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS (JP) | 1998-05-06 | — | — | EP | disclosed |
| US-5627193-A | MEDICAL DIAGNOSIS, CARDIOVASCULAR DIAORDERS AND PROTECTION OF ORGANS FOR TRANSPLANTATION | MITSUI TOATSU CHEMICALS, INC. (JP) | 1997-05-06 | — | — | US | disclosed |
| EP-0726254-A1 | Quinoline-4-carbonylguanidine derivates, process for producing the same and pharmaceutical preparations containing the compounds | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1996-08-14 | — | — | EP | disclosed |