Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MASP2 | O00187 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL725856 | 0.87 | MAPT (0.55) | MAOAMEN1KMT2AMAPTHTT | |
| SCHEMBL1796583 | 0.87 | MAPT (0.55) | MAOAMAOBMAPTHTTGFER | |
| 4-Chloroaniline SCHEMBL27544 | 0.79 | — | — | |
| 4-Chloroaniline SCHEMBL16922177 | 0.79 | — | — | |
| SCHEMBL10905142 | 0.78 | CA1 (0.42) | MAOAMAOBMEN1KMT2AMAPT | |
| SCHEMBL9823021 | 0.78 | MEN1 (0.54) | MAOAMAOBMEN1KMT2AMAPT | |
| SCHEMBL3695975 | 0.78 | CES2 (0.60) | MAOAMAOBMEN1KMT2AMAPT | |
| SCHEMBL4747566 | 0.76 | SRD5A2 (0.64) | MAOAMAOBMEN1KMT2AMAPT | |
| SCHEMBL18661442 | 0.76 | ACHE (0.62) | MAOAMEN1KMT2AMAPTHTT | |
| SCHEMBL6465868 | 0.76 | MAPT (0.44) | MAOAMAOBMAPTHTTGFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632017-B1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-05-06 | — | — | EP | disclosed |
| US-5416112-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-05-16 | — | — | US | disclosed |
| EP-0632017-A1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-01-04 | — | — | EP | disclosed |
| US-4587361-A | N-(4-(1-PHENYLETHENYL)PHENYL)-2-HYDROXY-3,5-DIHALOBENZAMIDE | SMITHKLINE BECKMAN CORPORATION (US) | 1986-05-06 | — | — | US | disclosed |