Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 3/20 | 0.45 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8613726 | 0.86 | TBXA2R (0.43) | NR3C1TBXA2RTBXAS1 | |
| SCHEMBL12142430 | 0.81 | HTR2A (0.43) | NR3C1TBXA2RHTR2AHTR2CHRH1 | |
| SCHEMBL12205621 | 0.81 | ACP3 (0.44) | NR3C1HTR2AHTR2CMAPK1 | |
| SCHEMBL12205541 | 0.81 | HDAC4 (0.46) | NR3C1HTR2AHTR2CHRH1MAPK1 | |
| SCHEMBL12205540 | 0.81 | NR3C1 (0.63) | NR3C1 | |
| SCHEMBL5756742 | 0.73 | ATM (0.43) | TBXA2RHTR2AHTR2CHRH1HSD17B3 | |
| SCHEMBL5756737 | 0.73 | ATM (0.43) | TBXA2RHTR2AHTR2CHRH1HSD17B3 | |
| SCHEMBL12205622 | 0.72 | POLB (0.44) | NR3C1ALDH1A1HSD17B10 | |
| SCHEMBL12205575 | 0.71 | NR3C1 (0.59) | NR3C1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL12205738 | 0.71 | NR3C1 (0.49) | NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588608-B1 | Tricyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO KK (JP) | 1998-05-06 | — | — | EP | disclosed |
| EP-0588608-A2 | Tricyclic compounds and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |