Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.68 |
| ▸ | MAOA | P21397 | 2/20 | 0.68 |
| ▸ | APP | P05067 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | FBP1 | P09467 | 3/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.59 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3366102 | 1.00 | MAOB (0.68) | MAOBMAOAAPPNPC1MAPT | |
| SCHEMBL3366106 | 1.00 | MAOB (0.68) | MAOBMAOAAPPNPC1MAPT | |
| SCHEMBL458177 | 0.89 | APP (0.78) | MAOBAPPNPC1MAPTRAB9A | |
| SCHEMBL458178 | 0.89 | APP (0.78) | MAOBAPPNPC1MAPTRAB9A | |
| SCHEMBL14947048 | 0.89 | APP (0.78) | MAOBAPPNPC1MAPTRAB9A | |
| SCHEMBL9170800 | 0.89 | APP (0.78) | MAOBAPPNPC1MAPTRAB9A | |
| SCHEMBL9170804 | 0.89 | APP (0.78) | MAOBAPPNPC1MAPTRAB9A | |
| SCHEMBL14880514 | 0.88 | MAOB (0.58) | MAOBMAOAAPPNPC1MAPT | |
| SCHEMBL2724772 | 0.87 | CYP1A2 (0.67) | MAOBMAOANPC1MAPTRAB9A | |
| SCHEMBL28180410 | 0.87 | CYP1A2 (0.67) | MAOBMAOANPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632017-B1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1998-05-06 | — | — | EP | disclosed |
| US-5416112-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1995-05-16 | — | — | US | disclosed |
| EP-0632017-A1 | N-phenyl-2-cyano-3-hydroxy propenamides, their tautomeres and salts, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-01-04 | — | — | EP | disclosed |