Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.37 |
| ▸ | MAN1B1 | Q9UKM7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8618404 | 1.00 | MAOA (0.44) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL6977437 | 0.75 | MAOA (0.45) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL6980288 | 0.75 | MAOA (0.45) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL6969440 | 0.67 | MEN1 (0.43) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL4932707 | 0.66 | MAOA (0.95) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL893154 | 0.66 | MAOA (0.86) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27426481 | 0.66 | MEN1 (0.42) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL4642587 | 0.65 | MAOA (1.00) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3524869 | 0.65 | MAOA (0.82) | MAOACHRM2SIGMAR1MEN1KMT2A | |
| SCHEMBL8851048 | 0.65 | MAOA (1.00) | MAOACHRM2SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824523-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. Searle & Co. (US) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035677-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. SEARLE & CO. (US) | 1996-11-14 | — | — | WO | disclosed |