SCHEMBL8618449

SCHEMBL8618449

CC(=O)Sc1ccc(S(=O)(=O)c2ccc(C)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.59
PKM P14618 3/20 0.54
DNMT1 P26358 1/20 0.48
MAPT P10636 8/20 0.47
LMNA P02545 3/20 0.47
HTT P42858 2/20 0.47
KDM4E B2RXH2 2/20 0.47
TDP1 Q9NUW8 1/20 0.47
ALDH1A1 P00352 5/20 0.46
MEN1 O00255 4/20 0.46
KMT2A Q03164 4/20 0.46
ALOX12 P18054 1/20 0.44
SMN1; SMN2 Q16637 2/20 0.43
POLB P06746 2/20 0.43
RAPGEF4 Q8WZA2 1/20 0.43
MPI P34949 1/20 0.43
MCL1 Q07820 1/20 0.43
APOBEC3G Q9HC16 1/20 0.43
HPGD P15428 2/20 0.42
CA1 P00915 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7518002 0.86 MAPT (0.50) GAAPKMDNMT1MAPTLMNA
SCHEMBL8618437 0.81 CA2 (0.46) GAAPKMMAPTKDM4EALDH1A1
SCHEMBL13749343 0.78 GAA (0.73) GAAPKMDNMT1MAPTLMNA
Acetamide SCHEMBL538407 0.78 GAA (0.73) GAAPKMMAPTLMNAHTT
SCHEMBL12298956 0.78 GAA (0.73) GAAPKMDNMT1MAPTLMNA
SCHEMBL10067072 0.77 GAA (1.00) GAAPKMDNMT1MAPTLMNA
SCHEMBL170033 0.77 GAA (1.00) GAAPKMDNMT1MAPTLMNA
SCHEMBL14341653 0.77 HPGD (0.46) GAAPKMMAPTLMNAHTT
SCHEMBL4400955 0.77 GAA (1.00) GAAPKMDNMT1MAPTLMNA
SCHEMBL463659 0.76 GAA (0.70) GAAPKMDNMT1MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0708086-B1 Bisguanidine salts and a method for releasing a base using the same salts FUJI PHOTO FILM CO LTD (JP) 1998-05-20 EP disclosed
US-5728879-A HEAT SENSITIVE ELEMENTS FOR RECORDING AND FORMING IMAGES FUJI PHOTO FILM CO., LTD. (JP) 1998-03-17 US disclosed
EP-0708086-A1 Bisguanidine salts and a method for releasing a base using the same salts FUJI PHOTO FILM CO., LTD. (JP) 1996-04-24 EP disclosed