Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 6/20 | 0.50 |
| ▸ | THRB | P10828 | 5/20 | 0.49 |
| ▸ | THRA | P10827 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | RARA | P10276 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | LPL | P06858 | 4/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 2/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | TACR2 | P21452 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8625001 | 0.94 | THRB (0.54) | THRBTHRAMEN1KMT2AALDH1A1 | |
| SCHEMBL8623292 | 0.89 | THRB (0.45) | RARBTHRBTHRAMEN1KMT2A | |
| SCHEMBL12035890 | 0.80 | CSNK1E (0.44) | RARBTHRBTHRAMEN1KMT2A | |
| SCHEMBL12035888 | 0.80 | CSNK1E (0.44) | RARBTHRBTHRAMEN1KMT2A | |
| SCHEMBL10333376 | 0.80 | RARB (0.56) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL9805784 | 0.80 | RARB (0.56) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL9498807 | 0.79 | RARB (0.54) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL9498972 | 0.78 | RARB (0.55) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL9498582 | 0.78 | RARB (0.55) | RARBMEN1KMT2AALDH1A1RARA | |
| SCHEMBL9498408 | 0.78 | RARB (0.55) | RARBMEN1KMT2AALDH1A1RARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5712396-A | PHOSPHONOSULFONATE COMPOUNDS USED FOR INHIBITING CHOLESTEROL BIOSYNTHESIS AND ATHEROSCLEROSIS | MAGNIN DAVID R (US) | 1998-01-27 | — | — | US | disclosed |
| US-5567841-A | ANTICHOLESTEROL AGENT | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-10-22 | — | — | US | disclosed |
| US-5470845-A | Methods of using α-phosphonosulfonate squalene synthetase inhibitors including the treatment of atherosclerosis and hypercholesterolemia | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-11-28 | — | — | US | disclosed |