Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 5/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.53 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 8/20 | 0.42 |
| ▸ | RXRB | P28702 | 8/20 | 0.42 |
| ▸ | RXRG | P48443 | 8/20 | 0.42 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LDHB | P07195 | 1/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | C5 | P01031 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5733857 | 0.90 | NR4A2 (0.50) | NR4A2NR4A1NR4A3PTGS2PTGS1 | |
| SCHEMBL5732493 | 0.88 | PTGS2 (0.51) | NR4A2NR4A1NR4A3PTGS2PTGS1 | |
| SCHEMBL7503465 | 0.87 | PTGS2 (0.62) | NR4A2NR4A1NR4A3PTGS2PTGS1 | |
| SCHEMBL5732336 | 0.85 | NR4A2 (0.60) | NR4A2NR4A1NR4A3PTGS2PTGS1 | |
| SCHEMBL5733069 | 0.85 | NR4A2 (0.60) | NR4A2NR4A1NR4A3PTGS2PTGS1 | |
| SCHEMBL5763378 | 0.85 | NR4A2 (0.75) | NR4A2NR4A1NR4A3PTGS2PTGS1 | |
| SCHEMBL5734304 | 0.85 | NR4A2 (0.75) | NR4A2NR4A1NR4A3PTGS2PTGS1 | |
| SCHEMBL5731953 | 0.84 | RXRA (0.59) | NR4A2NR4A1NR4A3PTGS2PTGS1 | |
| SCHEMBL7501079 | 0.83 | CA1 (0.47) | PTGS2PTGS1RXRARXRBRXRG | |
| SCHEMBL7508644 | 0.79 | CA1 (0.47) | PTGS2PTGS1LDHALDHBSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |