Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | APP | P05067 | 1/20 | 0.63 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.59 |
| ▸ | TUBB | P07437 | 2/20 | 0.59 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.59 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.59 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.59 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.59 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.59 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.59 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.59 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.59 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.59 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.59 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.59 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.59 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | IAPP | P10997 | 2/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL160048 | 1.00 | ALDH1A1 (0.64) | ALDH1A1APPTUBB4ATUBBTUBA3C | |
| SCHEMBL17746768 | 0.98 | APP (0.66) | ALDH1A1APPTUBB4ATUBBTUBA3C | |
| SCHEMBL10954039 | 0.98 | APP (0.66) | ALDH1A1APPTUBB4ATUBBTUBA3C | |
| SCHEMBL3398185 | 0.98 | APP (0.66) | ALDH1A1APPTUBB4ATUBBTUBA3C | |
| SCHEMBL3398186 | 0.98 | APP (0.66) | ALDH1A1APPTUBB4ATUBBTUBA3C | |
| SCHEMBL9019324 | 0.98 | APP (0.66) | ALDH1A1APPTUBB4ATUBBTUBA3C | |
| SCHEMBL547240 | 0.98 | APP (0.66) | ALDH1A1APPTUBB4ATUBBTUBA3C | |
| SCHEMBL157815 | 0.98 | APP (0.66) | ALDH1A1APPTUBB4ATUBBTUBA3C | |
| SCHEMBL3395879 | 0.95 | ALDH1A1 (0.66) | ALDH1A1APPTUBB4ATUBBTUBA3C | |
| SCHEMBL3395878 | 0.95 | ALDH1A1 (0.66) | ALDH1A1APPTUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440705-B2 | 2,3,4,7,8,9-hexahydro-1H-cyclopenta[h]quinolin-2-one or 2,3,4,6,7,8-hexahydro-1H-cyclopenta[g]quinolin-2-one; Alzheimer's disease | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2013-05-14 | — | — | US | disclosed |
| EP-2433634-A3 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-07-18 | — | — | EP | disclosed |
| EP-2433634-A2 | Compounds, compositions and methods of inhibiting a-synuclein toxicity | The Whitehead Institute for Biomedical Research (US) | 2012-03-28 | — | — | EP | disclosed |
| CN-102379872-A | Compounds, compositions and methods of inhibiting a-synuclein toxicity | WHITEHEAD BIOMEDICAL INST | 2012-03-21 | — | — | CN | disclosed |
| EP-1802303-B1 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD BIOMEDICAL INST (US) | 2011-11-02 | — | — | EP | disclosed |
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2008-10-23 | — | — | US | disclosed |
| EP-1961453-A2 | Benzyliden-ß-dicarbonyl compounds as UV-absorbers | Symrise GmbH & Co. KG (DE) | 2008-08-27 | — | — | EP | disclosed |
| CN-101060839-A | Compounds, compositions and methods for inhibiting alpha-synuclein toxicity | WHITEHEAD BIOMEDICAL INST (US) | 2007-10-24 | — | — | CN | disclosed |
| EP-1802303-A2 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006034003-A3 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD BIOMEDICAL INST (US) | 2006-07-13 | — | — | WO | disclosed |
| WO-2006034003-A2 | COMPOUNDS, COMPOSITIONS AND METHODS OF INHIBITING A-SYNUCLEIN TOXICITY | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080261953-A1 | Compounds, Compositions and Methods of Inhibiting Alpha-Synuclein Toxicity | SNCA, PARK7, HTT | ALDH1A1 171/4885APP 17/4885TUBB4A 463/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.