SCHEMBL8619306

SCHEMBL8619306

Fc1cc(-c2cccc(F)c2F)ccc1OCc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ERN1 O75460 1/20 0.47
MRGPRX4 Q96LA9 3/20 0.47
KDM1A O60341 4/20 0.46
FFAR1 O14842 4/20 0.46
S1PR5 Q9H228 1/20 0.45
PPARD Q03181 1/20 0.45
CTSA P10619 1/20 0.44
PTGER1 P34995 4/20 0.44
MCL1 Q07820 1/20 0.44
PTGER4 P35408 1/20 0.43
PTGER3 P43115 1/20 0.43
PTGER2 P43116 1/20 0.43
FEN1 P39748 1/20 0.42
CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8612495 0.96 FEN1 (0.47) ERN1MRGPRX4KDM1AFFAR1S1PR5
SCHEMBL8612994 0.94 ERN1 (0.48) ERN1MRGPRX4KDM1AFFAR1S1PR5
SCHEMBL8616588 0.91 ERN1 (0.47) ERN1MRGPRX4KDM1AFFAR1S1PR5
SCHEMBL8614212 0.88 FEN1 (0.43) ERN1MRGPRX4KDM1AFFAR1PTGER1
SCHEMBL8616573 0.86 KDM1A (0.46) MRGPRX4KDM1APTGER1MCL1PTGER4
SCHEMBL8612218 0.82 FFAR1 (0.47) FFAR1PPARDPTGER4PTGER3
SCHEMBL8612148 0.82 GSTP1 (0.54) FFAR1PTGER4PTGER3FEN1
SCHEMBL8615456 0.82 ERN1 (0.45) ERN1MRGPRX4KDM1AFFAR1S1PR5
SCHEMBL16572511 0.81 FGFR1 (0.49) KDM1AFFAR1PPARDCTSA
SCHEMBL8614099 0.81 KDM1A (0.49) MRGPRX4KDM1AS1PR5PTGER1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0665836-B1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AG (DE) 1998-04-29 EP disclosed
WO-1994010152-A1 BIFUNCTIONAL INTERMEDIATES FOR USE IN THE MANUFACTURE OF LIQUID CRYSTALS HOECHST AKTIENGESELLSCHAFT (DE) 1994-05-11 WO disclosed