SCHEMBL8619367

SCHEMBL8619367

NOc1nc(N)nc2nc[nH]c12

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 15/20 0.66
CCNB1 P14635 15/20 0.66
CDK2 P24941 15/20 0.66
CCNA2 P20248 14/20 0.66
CCNA1 P78396 14/20 0.66
MGMT P16455 6/20 0.62
PIN1 Q13526 2/20 0.62
PDPK1 O15530 1/20 0.61
GDA Q9Y2T3 1/20 0.61
LMNA P02545 1/20 0.59
CYP1A2 P05177 1/20 0.59
CYP3A4 P08684 1/20 0.59
CYP2D6 P10635 1/20 0.59
CYP2C9 P11712 1/20 0.59
TSHR P16473 1/20 0.59
NFKB1 P19838 1/20 0.59
CYP2C19 P33261 1/20 0.59
BLM P54132 1/20 0.59
PMP22 Q01453 1/20 0.59
DPP4 P27487 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methylguanine SCHEMBL231097 0.84 CDK1 (0.69) CDK1CCNB1CDK2CCNA2CCNA1
Methylguanine SCHEMBL29903462 0.84 CDK1 (0.69) CDK1CCNB1CDK2CCNA2CCNA1
SCHEMBL8618498 0.81 CDK1 (0.77) CDK1CCNB1CDK2CCNA2CCNA1
SCHEMBL30176198 0.81 CDK1 (0.77) CDK1CCNB1CDK2CCNA2CCNA1
SCHEMBL5201806 0.81 CDK1 (0.65) CDK1CCNB1CDK2CCNA2CCNA1
SCHEMBL9682498 0.80 CDK1 (1.00) CDK1CCNB1CDK2CCNA2CCNA1
SCHEMBL9682544 0.79 CDK1 (0.63) CDK1CCNB1CDK2CCNA2CCNA1
SCHEMBL8971208 0.78 CDK1 (1.00) CDK1CCNB1CDK2CCNA2CCNA1
SCHEMBL9682546 0.77 CDK1 (0.66) CDK1CCNB1CDK2CCNA2CCNA1
SCHEMBL7807585 0.77 CDK1 (0.76) CDK1CCNB1CDK2CCNA2CCNA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5817799-A 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1998-10-06 US claimed
EP-0540686-B1 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES US COMMERCE (US) 1995-08-30 EP claimed
EP-0540686-A4 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES US COMMERCE (US) 1993-05-26 EP claimed
EP-0540686-A1 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES. US COMMERCE (US) 1993-05-12 EP claimed
WO-1992001700-A1 2'-FLUOROFURANOSYL DERIVATIVES AND NOVEL METHOD OF PREPARING 2'-FLUOROPYRIMIDINE AND 2'-FLUOROPURINE NUCLEOSIDES THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, U.S. DEPARTMENT OF COMMERCE (US) 1992-02-06 WO claimed