Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.50 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.50 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.50 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.50 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.50 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385822 | 0.95 | KDM4E (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1969569 | 0.90 | TSHR (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3814418 | 0.90 | TSHR (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6979320 | 0.79 | KDM4E (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL18014873 | 0.78 | HCAR2 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL23056654 | 0.78 | PTGS2 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29169544 | 0.78 | PTGS2 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL793526 | 0.78 | PTGS2 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL17144120 | 0.77 | LMNA (0.49) | LMNATSHRCTSLCTSBCTSK | |
| SCHEMBL17610572 | 0.77 | LMNA (0.46) | LMNATSHRCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101723945-B | Method for preparing antiviral medicinal entecavir intermediate | SHANGHAI QINGSONG PHARMACEUTICAL CO LTD | 2011-11-02 | — | — | CN | disclosed |
| CN-101723945-A | Method for preparing antiviral medicinal entecavir intermediate | SHANGHAI QINGSONG PHARMACEUTIC | 2010-06-09 | — | — | CN | disclosed |
| EP-0730577-B1 | 26,28-METHYLENE-1ALPHA,25-DIHYDROXYVITAMIN D2 COMPOUNDS | WISCONSIN ALUMNI RES FOUND (US) | 1998-05-06 | — | — | EP | disclosed |
| EP-0730577-A1 | 26,28-METHYLENE-1ALPHA,25-DIHYDROXYVITAMIN D 2 COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1996-09-11 | — | — | EP | disclosed |
| US-5457217-A | Treating bone disorders, osteoporosis | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1995-10-10 | — | — | US | disclosed |
| WO-1995014662-A1 | 26,28-METHYLENE-1ALPHA,25-DIHYDROXYVITAMIN D2 COMPOUNDS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1995-06-01 | — | — | WO | disclosed |
| US-5373004-A | Cyclopentane ring introduced into side chain; administering for treatment of osteoporosis | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1994-12-13 | — | — | US | disclosed |
| EP-0353732-A2 | Fluoro-olefins, method for their preparation and their use | CIBA-GEIGY AG (CH) | 1990-02-07 | — | — | EP | disclosed |