Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.46 |
| ▸ | KDM5A | P29375 | 7/20 | 0.46 |
| ▸ | KDM4A | O75164 | 3/20 | 0.46 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 4/20 | 0.45 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.45 |
| ▸ | KDM7A | Q6ZMT4 | 2/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.44 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.44 |
| ▸ | PHF2 | O75151 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8623692 | 0.92 | THRA (0.47) | THRATHRBABCB1KDM5AKDM4A | |
| SCHEMBL8617598 | 0.88 | THRA (0.51) | THRATHRBABCB1KDM5AKDM4A | |
| SCHEMBL8618732 | 0.87 | THRA (0.66) | THRATHRBABCB1KDM5AKDM4A | |
| SCHEMBL8624417 | 0.83 | THRA (0.48) | THRATHRBABCB1KDM5AKDM4A | |
| SCHEMBL8620718 | 0.82 | SLC22A12 (0.45) | ABCB11CHRM2ADRA2AADORA3CHRM1 | |
| SCHEMBL8618898 | 0.82 | THRA (0.55) | THRATHRBABCB1KDM5AKDM4A | |
| SCHEMBL8619765 | 0.79 | THRA (0.67) | THRATHRBABCB1KDM5AKDM4A | |
| SCHEMBL8621631 | 0.79 | THRA (0.52) | THRATHRBABCB1KDM5AKDM4A | |
| SCHEMBL8620054 | 0.78 | THRA (0.65) | THRATHRBABCB1KDM5AKDM4A | |
| SCHEMBL8622615 | 0.78 | MAPT (0.40) | THRBALDH1A1TP53CYP1A2NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |
| EP-0775129-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005190-A1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KARO BIO AB (SE) | 1996-02-22 | — | — | WO | disclosed |