Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | KDM4A | O75164 | 1/20 | 0.45 |
| ▸ | KDM5A | P29375 | 1/20 | 0.45 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
| ▸ | EYA3 | Q99504 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619478 | 0.92 | THRA (0.48) | THRATHRBABCB1KDM4AKDM5A | |
| SCHEMBL8620718 | 0.91 | SLC22A12 (0.45) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL8617598 | 0.87 | THRA (0.51) | THRATHRBABCB1KDM4AKDM5A | |
| SCHEMBL8622615 | 0.87 | MAPT (0.40) | THRB | |
| SCHEMBL8620054 | 0.87 | THRA (0.65) | THRATHRBABCB1KDM4AKDM5A | |
| SCHEMBL8624399 | 0.83 | THRA (0.47) | THRATHRBABCB1KDM4AKDM5A | |
| SCHEMBL8618898 | 0.81 | THRA (0.55) | THRATHRBABCB1KDM4AKDM5A | |
| SCHEMBL8624417 | 0.81 | THRA (0.48) | THRATHRBABCB1KDM4AKDM5A | |
| SCHEMBL8622465 | 0.80 | THRA (0.66) | THRATHRBABCB1KDM4AKDM5A | |
| SCHEMBL8622473 | 0.79 | THRA (0.51) | THRATHRBSIRT3ESR1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5854282-A | 3-benzoyl benzofuran derivatives as thyroid hormone antagonists | KARO BIO AB (SE) | 1998-12-29 | — | — | US | disclosed |
| EP-0775129-B1 | 3-BENZOYL BENZOFURAN DERIVATIVES AS THYROID HORMONE ANTAGONISTS | KAROBIO AB (SE) | 1998-10-21 | — | — | EP | disclosed |