Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.51 |
| ▸ | HTR1B | P28222 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 14/20 | 0.46 |
| ▸ | HTR2A | P28223 | 14/20 | 0.46 |
| ▸ | HTR2B | P41595 | 9/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614116 | 0.95 | HTR1D (0.57) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8617369 | 0.86 | HTR1D (0.59) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8617984 | 0.86 | HTR1D (0.65) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8616138 | 0.86 | HTR1D (0.57) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8613994 | 0.80 | HTR1A (0.57) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8137992 | 0.79 | HTR1A (0.72) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8618094 | 0.77 | HTR1A (0.62) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8623325 | 0.76 | HTR2C (0.51) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8128398 | 0.74 | HTR1D (0.70) | HTR1DHTR1BHTR1AHTR2CHTR2A | |
| SCHEMBL8127323 | 0.74 | HTR1A (0.81) | HTR1DHTR1BHTR1AHTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |